Role
Senior Lecturer in Molecular Cell Biology
Dr Marion Hogg is module lead for the Experimental Design module on the MBiol course and contributes to the Practical Techniques (UG) and Research Methods and Bioethics (PG) modules. She supervises laboratory research projects at undergraduate and postgraduate levels, and acts as a personal tutor. Marion's research focuses on the role of transfer RNA fragments in neuronal heath and neurodegenerative disease.
Research areas
transfer RNAs (tRNAs) play a crucial role in protein translation where they bring amino acids to the ribosome to be added to nascent proteins. However under stress conditions tRNAs can be cleaved to generate short tRNA fragments, which may function in a similar way to microRNAs. My research program investigates the biogenesis and function of tRNA fragments in neurons to determine their role in neurological and neurodegenerative diseases.
tRNA fragments are stable and can be detected circulating in blood indicating they could be of use a biomarkers for a range of different disorders. Dr Hogg identified three specific tRNA fragments that are elevated in advance of seizures in people with epilepsy and subsequently developed a direct detection method capable of quantifying tRNA fragments in small volumes of biofluids. Our research was reviewed in and we made a and wrote a about these studies.
Publications
Hogg MC, Rayner M, Susdalzew S, Monsefi N, Crivello M, Woods I, Resler A, Blackbourn L, Fabbrizio P, Trolese MC, Nardo G, Bendotti C, van den Berg LH, van Es MA, Prehn JHM. Brain Commun. 2020 Aug 28;2(2):fcaa138. doi: 10.1093/braincomms/fcaa138. eCollection 2020.
McArdle H, Hogg MC, Bauer S, Rosenow F, Prehn JHM, Adamson K, Henshall DC, Spain E. Sci Rep. 2020 May 5;10(1):7516. doi: 10.1038/s41598-020-64485-4.
Khan A, Paro S, McGurk L, Sambrani N, Hogg MC, Brindle J, Pennetta G, Keegan LP, O'Connell MA. BMC Biol. 2020 Feb 14;18(1):15. doi: 10.1186/s12915-020-0747-0.
Crivello M, Hogg MC, Jirström E, Halang L, Woods I, Rayner M, Coughlan KS, Lewandowski SA, Prehn JHM. Dis Model Mech. 2019 Aug 13;12(8):dmm040238. doi: 10.1242/dmm.040238. .
Hogg MC, Raoof R, El Naggar H, Monsefi N, Delanty N, O'Brien DF, Bauer S, Rosenow F, Henshall DC, Prehn JH. J Clin Invest. 2019 Apr 30;129(7):2946-2951. doi: 10.1172/JCI126346. on our research and a explaining the study.
Crivello M, O'Riordan SL, Woods I, Cannon S, Halang L, Coughlan KS, Hogg MC, Lewandowski SA, Prehn JHM. Neuropharmacology. 2018 May 1;133:503-511. doi: 10.1016/j.neuropharm.2018.02.022. Epub 2018 Feb 25.
Hogg MC, Halang L, Woods I, Coughlan KS, Prehn JHM. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):438-445. doi: 10.1080/21678421.2017.1407796. Epub 2017 Dec 8.
Hogg MC, Mitchem MR, König HG, Prehn JH. Biochim Biophys Acta. 2016 Jun;1862(6):1063-73. doi: 10.1016/j.bbadis.2016.03.006. Epub 2016 Mar 11.
Coughlan KS, Mitchem MR, Hogg MC, Prehn JH. Neurobiol Aging. 2015 Feb;36(2):1140-50. doi: 10.1016/j.neurobiolaging.2014.09.022. Epub 2014 Sep 26.