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Craig Doig

Craig Doig

Associate Professor

School of Science & Technology

Staff Group(s)
Bioscience

Role

Craig is an Associate Professor of Metabolic Health. He is interested in the basic mechanistic biology of both cells and tissue systems, working to apply this understanding towards treatment strategies targeting human disease. The laboratory are focussed upon the mechanisms and metabolic roles of NAD+ consuming enzymes and interactions with steroid hormone signaling.

Career overview

Prior to his career in academia, Craig was an analytical scientist working with 3M Health Care, Astra-Zeneca, Merck and Sanofi-Aventis. For his doctoral training Craig was located at Roswell Park Cancer Institute, Buffalo, New York USA. Here he studied mechanisms of transcriptional control in cancer, employing epigenetic techniques and DNA methylation analysis. As a postdoctoral researcher, Craig trained within the fields of endocrinology and molecular metabolism at the Centre for Endocrinology Diabetes & Metabolism and the Institute of Metabolism & Systems Research at University of Birmingham. His work revealing the roles of steroid hormone biochemistry and its impacts upon tissues including brown adipose and skeletal muscle. These projects have helped define current understanding of endocrinology, metabolism and mitochondrial function.

Research areas

Craig is strongly interested in the regulation of physiology, endocrinology, epigenetic signalling and how they impact metabolic pathways in health and disease.

Fully funded PhD Studentships are available in this lab - Please email Craig directly for further information.

Opportunities arise to carry out postgraduate research towards an MPhil / PhD in the areas identified above. Further information may be obtained on the NTU Research Degrees website /research/research-degrees-at-ntu

Publications

  1. Contribution of local regeneration of glucocorticoids to tissue steroid pools. Khan S, Livingstone DEW, Zielinska A, Doig CL, Cobice DF, Esteves CL, Man JTY, Homer NZM, Seckl JR, MacKay CL, Webster SP, Lavery GG, Chapman KE, Walker BR, Andrew R. J Endocrinol. 2023.
  2. PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response. Tan A, Younis AZ, Evans A, Creighton JV, Coveney C, Boocock D, Sale C, Lavery GG, Coutts A, Doig CL. Cell Death and Discovery. 2023.
  3. Rapid isolation of respiring skeletal muscle mitochondria using nitrogen cavitation. Younis AZ, Lavery GG, Christian M, Doig CL. Frontiers in Physiology. 2023.
  4. Contribution of local versus systemic regeneration of glucocorticoids to tissue steroid pools. Khan S, Livingstone DEW, Zielinska A, Doig CL, Cobice DF, Esteves C, Man J, Homer NZM, Seckl JR, MacKay CL, Webster SP, Lavery GG, Walker BR, Andrew R. Journal of Endocrinology. Accepted 2023.
  5. Spatial proteomics reveals heterogeneity of neural marker expression underpinning the metabolic response to high fat diet induced myopathy in mice. Hardowar L, Vadakekolathu Narayanan J, Rutella S, Hulse R, Doig CL. Journal of Molecular Endocrinology.Under revision 2023.
  6. Lavilla CJ, Billacura MP, Hanna K, Boocock DJ, Coveney C, Miles AK, Foulds GA, Murphy A, Tan A, Jackisch L, Sayers SR, Caton PW, Doig CL, McTernan PG, Colombo SL, Sale C, Turner MD. Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress. Free Radical Biology and Medicine. 2021.
  7. Cartwright DM, Oakey LA, Fletcher RS, Doig CL, Heising S, Larner DP, Nasteska D, Berry CE, Heaselgrave SR, Ludwig C, Hodson DJ, Lavery GG, Garten A. Journal of Endocrinology. 2021.
  8. Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG. Skeletal Muscle. 2020.
  9. Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG. Wellcome Open Research. 2020.
  10. Fenton CG, Doig CL, Fareed S, Naylor A, Morrell AP, Addison O, Wehmeyer C, Buckley CD, Cooper MS, Lavery GG, Raza K, Hardy RS. Arthritis Research & Therapy. 2019.
  11. Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG.Cell Reports. 2019.
  12. Chortis V, Taylor AE, Doig CL, Walsh MD, Meimaridou E, Jenkinson C, Rodriguez-Blanco G, Ronchi CL, Jafri A, Metherell LA, Hebenstreit D, Dunn WB, Arlt W, Foster PA. Endocrinology. 2018.
  13. Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Diabetes. 2018.
  14. Fletcher RS, Ratajczak J, Doig CL, Oakey LA, Callingham R, Da Silva Xavier G, Garten A, Elhassan YS, Redpath P, Migaud ME, Philp A, Brenner C, Canto C, Lavery GG. Molecular Metabolism. 2017.
  15. Zielinska AE, Fletcher RS, Sherlock M, Doig CL, Lavery GG. Cell Biochemistry & Function. 2017.
  16. Doig CL, Fletcher RS, Morgan SA, McCabe EL, Larner DP, Tomlinson JW, Stewart PM, Philp A, Lavery GG. Endocrinology. 2017.
  17. Hardy RS, Doig CL, Hussain Z, O'Leary M, Morgan SA, Pearson MJ, Naylor A, Jones SW, Filer A, Stewart PM, Buckley CD, Lavery GG, Cooper MS, Raza K. Journal of Pathology. 2016.
  18. Larner DP, Morgan SA, Gathercole LL, Doig CL, Guest P, Weston C, Hazeldine J, Tomlinson JW, Stewart PM, Lavery GG. Endocrinology. 2016.
  19. Morgan SA, Hassan-Smith ZK, Doig CL, Sherlock M, Stewart PM, Lavery GG. Journal of Endocrinology. 2016.
  20. Doig CL, Battaglia S, Khanim FL, Bunce CM, Campbell MJ. Journal of Steroid Biochemistry & Molecular Biology. 2016.
  21. Doig CL, Bashir J, Zielinska AE, Cooper MS, Stewart PM, Lavery GG.  Journal of Endocrinology. 2014.
  22. Singh PK, Doig CL, Dhiman VK, Turner BM, Smiraglia DJ, Campbell MJ. Journal of Steroid Biochemistry & Molecular Biology. 2013.
  23. Doig CL, Singh PK, Dhiman VK, Thorne JL, Battaglia S, Sobolewski M, Maguire O, O'Neill LP, Turner BM, McCabe CJ, Smiraglia DJ, Campbell MJ. Carcinogenesis. 2013.
  24. A switch in hepatic cortisol metabolism across the spectrum of non-alcoholic fatty liver disease. Ahmed A, Rabbitt E, Brady T, Brown C, Guest P, Bujalska IJ, Doig C, Newsome PN, Hubscher S, Elias E, Adams DH, Tomlinson JW, Stewart PM. PLoS One. 2012.
  25. Thorne JL, Maguire O, Doig CL, Battaglia S, Fehr L, Sucheston LE, Heinaniemi M, O'Neill LP, McCabe CJ, Turner BM,  Campbell MJ. Nucleic Acids Research. 2011.
  26. Battaglia S, Maguire O, Thorne JL, Hornung LB, Doig CL, Liu S, Sucheston LE, Bianchi A, Khanim FL, Gommersall LM, Coulter HS, Rakha S, Giddings I, O'Neill LP, Cooper CS, McCabe CJ, Bunce CM, Campbell MJ. Carcinogenesis. 2010.
  27. Watkins RJ, Read ML, Smith VE, Sharma N, Reynolds GM, Buckley L, Doig C, Campbell MJ, Lewy G, Eggo MC, Loubiere LS, Franklyn JA, Boelaert K, McCabe CJ. Cancer Research. 2010.

REVIEW ARTICLES

  1. Tan A, Doig CL. NAD+ Degrading Enzymes, Evidence for Roles During Infection. Frontiers Molecular Biosciences. 2021.
  2. Creighton JV, de Souza Goncalves L, Artiolo GG, Tan D, Elliot-Sale KJ, Turner MD, Doig CL, Sale C. Physiological Roles of carnosine in myocardial function and health. Advances in Nutrition. 2022.
  3. PARP Inhibitors: Staying on Target? Doig CL, Lavery GG.Cell Chemical Biology. 2016.
  4. Molecular roles of ADP-Ribosylation in the infection and immune response to Trypanosoma Cruzi.  Dowling J, Doig CL. Pathogens. 2023.