Role
Dr Antonchick leads the research group, teaches undergraduate and postgraduate organic chemistry and is module leader for research projects at the department.
Career overview
Andrey P. Antonchick studied chemistry at Belarusian State University (Minsk, Belarus). He received a PhD in bioorganic chemistry from the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus (Minsk, Belarus) and the Max Planck Institute for Chemical Ecology (Jena, Germany) under the guidance of Prof. V.A. Khripach and PD Dr. B. Schneider. After a postdoctoral appointment with Prof. M. Rueping at Frankfurt University, he joined the group of Prof H. Waldmann at the Max Planck Institute of Molecular Physiology (Dortmund, Germany). In 2011 he was appointed group leader at the Max Planck Institute of Molecular Physiology and Technical University of Dortmund. Since August 2020, he holds the position of Associate Professor at the ŷ. |
Research areas
The research of the group is based on chemical synthesis. We focus on the development of novel methods for the synthesis of small compounds and following application of the developed reaction methodology for preparation of focused compound libraries. Obtained compounds are studied using cell based assays and chemical genetic approaches to evaluate possible targets. Furthermore, we are elaborating new synthetic strategies for the preparation of complex lead molecules with pronounced bioactivity.
The group’s research covers several complementary areas of organic synthesis for the development of novel efficient reaction methodology, such as:
- Enantioselective catalysis for the synthesis of complex chiral products with multiple stereocenters
- C-H bond activation using transition metal catalysis for direct coupling of non-functionalized compounds
- C-H bond functionalization based on utilization of direct oxidative metal-free methods for synthesis of compounds of interest
Publications
Please, see the list of publications
List of selected publications
Hui C.; Craggs L.; Antonchick, A.P. Ring contraction in synthesis of functionalized carbocycles. Chem. Soc. Rev., 2022, 51, 8652-8675, DOI:
Hui C.; Brieger L.; Strohmann, C.; Antonchick, A.P. Stereoselective Synthesis of Cyclobutanes by Contraction of Pyrrolidines. J. Am. Chem. Soc. 2021, 123, 18864-18870, DOI:
Li H., Gontla R., Flegel J., Merten C., Ziegler S., Antonchick A. P.*, Waldmann H*. Enantioselective Formal C(sp3)‐H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives. Angew. Chem., Int. Ed. 2019, 58, 307-311, DOI: Angew. Chem. 2019, 131, 313-317, DOI:10.1002/ange.201811041
Manna S., Antonchick A. P. Catalytic Transfer Hydrogenation Using Biomass as Hydrogen Source. ChemSusChem 2019, 12, 3094-3098, DOI:
Shan G., Flegel J., Li H., Merten C., Ziegler S., Antonchick A. P.*, Waldmann H*. C–H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors. Angew. Chem., Int. Ed. 2018, 57, 14250-14254, DOI: Angew. Chem. 2018, 130, 14446-14450, DOI:10.1002/ange.201812882
Jia Z-J., Shan G., Daniliuc C.G., Daniliuc C.G., Antonchick A. P.*, Waldmann H*. Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis. Angew. Chem., Int. Ed. 2018, 57, 14493-14497, DOI:. Angew. Chem. 2018, 130, 14701-14705, DOI:
Xu H., Laraia L., Schneider L., Louven K., Strohmann C., Antonchick A. P.*, Waldmann H*. Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors. Angew. Chem., Int. Ed. 2017, 56, 11232-11236 , DOI:. Angew. Chem. 2017, 129, 11384-11388, DOI:
Jia Z-J., Merten C., Gontla R., Daniliuc C.G., Antonchick A. P.*, Waldmann H*. General Enantioselective C−H Activation with Efficiently Tunable Cyclopentadienyl Ligands. Angew. Chem., Int. Ed. 2017, 56, 2429-2434, DOI:. Angew. Chem. 2017, 129, 2469-2474, DOI:
Bering L., Antonchick A. P. Selective Transition-Metal-Free Vicinal cis-Dihydroxylation of Saturated Hydrocarbons. Chem. Sci. 2017, 8, 452-457, DOI:.
Xu H., Golz C., Strohmann C., Antonchick A. P.*, Waldmann H*. Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition. Angew. Chem., Int. Ed. 2016, 55, 7761-7765, DOI:. Angew. Chem. 2016, 128, 7892-7896, DOI:
Manna S., Antonchick A. P. [1+1+1] Cyclotrimerization for the Synthesis of Cyclopropanes. Angew. Chem., Int. Ed. 2016, 55, 5290-5293, DOI:. Angew. Chem. 2016, 128, 5376-5379, DOI:
Manna S., Antonchick A. P. Copper-Catalyzed (2+1) Annulation of Acetophenones with Maleimides: Direct Synthesis of Cyclopropanes. Angew. Chem., Int. Ed. 2015, 54, 14845-14848, DOI:. Angew. Chem. 2015, 127, 15058-15061, DOI:
Murarka S., Jia Z.-J., Merten C., Daniliuc C.-G., Antonchick A. P.*, Waldmann H*. Rhodium(II)-Catalyzed Enantioselective Synthesis of Troponoids. Angew. Chem., Int. Ed. 2015, 54, 7653-7656, DOI:. Angew. Chem. 2015, 127, 7763-7766, DOI:
Matcha K., Antonchick A.P. Cascade Multicomponent Synthesis of Indoles, Pyrazoles, and Pyridazinones by Functionalization of Alkenes. Angew. Chem., Int. Ed. 2014, 53, 11960-11964, DOI:. Angew. Chem. 2014, 126, 12154-12158, DOI:
Manna S., Matcha K., Antonchick A.P. Metal-Free Annulation of Arenes with 2-Aminopyridine Derivatives: The Methyl Group as a Traceless Non-Chelating Directing Group. Angew. Chem., Int. Ed. 2014, 53, 8163-8166, DOI:. Angew. Chem. 2014, 126, 8302-8305, DOI:
Manna S., Antonchick A.P. Organocatalytic Oxidative Annulation of Benzamide Derivatives with Alkynes. Angew. Chem., Int. Ed. 2014, 53, 7324-7327, DOI:. Angew. Chem. 2014, 126, 7452-7455, DOI:
Narayan R., Potowski M., Jia Z-J., Antonchick A.P.*, Waldmann H.* Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis. Acc. Chem. Res., 2014, 47, 1296-1310, DOI:
Narayan R., Bauer J. O., Strohmann C., Antonchick A.P.*, Waldmann H.* Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling. Angew. Chem., Int. Ed. 2013, 52, 12892-12896, DOI:. Angew. Chem. 2013, 125, 13130-13134, DOI:
Takayama H., Jia Z.-J., Kremer L., Bauer J.O., Strohmann C., Ziegler S., Antonchick A.P.*, Waldmann H.* Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid-Inspired Compound Collection. Angew. Chem., Int. Ed. 2013, 52, 12404-12408, DOI:. Angew. Chem. 2013, 125, 12630-12634, DOI:
Matcha K., Narayan R., Antonchick A.P., Metal-Free Radical Azidoarylation of Alkenes: Rapid Access to Oxindoles by Cascade C-N and C-C Bond-Forming Reactions. Angew. Chem., Int. Ed. 2013, 52, 7985-7989, DOI:. Angew. Chem. 2013, 125, 8143-8147, DOI:
Antonchick A.P., Burgmann L. Direct Selective Oxidative Cross-Coupling of Simple Alkanes with Heteroarenes. Angew. Chem., Int. Ed. 2013, 52, 3267-3271, DOI:. Angew. Chem. 2013, 125, 3349-3353, DOI:
Matcha K., Antonchick A.P. Metal-Free Cross-Dehydrogenative Coupling of Heterocycles with Aldehydes. Angew. Chem., Int. Ed. 2013, 52, 2082-2086, DOI:. Angew. Chem. 2013, 125, 2136-2140, DOI:
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